Neuroblastoma survivors are at increased risk for second malignancies: A report from the International Neuroblastoma Risk Group Project

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• 作者：Mark A. Applebaum^a ; Zalman Vaksman^b ; ^c ; Sang Mee Lee^d ; Eric A. Hungate^a ; Tara O. Henderson^a ; Wendy B. London^e ; Navin Pinto^f ; Samuel L. Volchenboum^a ; Julie R. Park^f ; Arlene Naranjo^g ; Barbara Hero^h ; Andrew D. Pearsonⁱ ; Barbara E. Stranger^j ; ^k ; Susan L. Cohn^a ; Sharon J. Diskin^b ; ^c ; ^l ; ^m ; ^{diskin@email.chop.edu}
• 关键词：Neuroblastoma ; Second malignant neoplasms ; INRG ; Genetic association study
• 刊名：European Journal of Cancer
• 出版年：2017
• 出版时间：February 2017
• 年：2017
• 卷：72
• 期：Complete
• 页码：177-185
• 全文大小：561 K
• 卷排序：72

文摘

High-risk neuroblastoma survivors are at 17.5-fold greater risk of second cancers. There is a high prevalence of secondary leukaemia in neuroblastoma survivors. Variants in DNA repair genes are most closely associated with second malignancies.