Fast and simultaneous determination of nimesulide and paracetamol by batch injection analysis with amperometric detection on bare boron-doped diamond electrode
详细信息 查看全文
- 作者：Polyana Fern ; es Pereira ; Mariana Cardoso Marra ; Am ; a Barbosa Lima ; Wallans Torres Pio dos Santos ; Rodrigo Alej ; ro Abarza Munoz ; Eduardo Mathias Richter
- 关键词：BIA-MPA ; batch injection analysis with multiple pulse amperometric detection ; BDD ; boron-doped diamond ; NIM ; nimesulide ; PAR ; paracetamol ; FIA ; flow injection analysis
- 刊名：Diamond and Related Materials
- 出版年：2013
- 出版时间：October, 2013
- 年：2013
- 卷：39
- 期：Complete
- 页码：41-46
- 全文大小：558 K
文摘
A fast and simple procedure for simultaneous determination of nimesulide and paracetamol (acetaminophen) was carried out by batch injection analysis with multiple pulse amperometric detection (BIA-MPA). The purpose is achieved with a unique and simple injection of a sample aliquot (150 ¦ÌL) onto the unmodified boron-doped diamond (BDD) electrode immersed in a BIA system. The analytical characteristics of our proposed method include elevated analytical frequency (up to 46 injections per hour), high stability (RSD < 1.3 % ; n = 12), low detection limits (0.293 and 0.297 mg L? 1 for paracetamol and nimesulide, respectively) and minimal waste generation. The proposed method presented similar results to those obtained by liquid chromatography at a 95 % confidence level.