Antidepressants, antimicrobials or both? Gut microbiota dysbiosis in depression and possible implications of the antimicrobial effects of antidepressant drugs for antidepressant effectiveness

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• 作者：Danielle Macedo^a ; ¹ ; ^{daniellesilmacedo@gmail.com} ; ^{danielle.macedo@ufc.br} ; Adriano José ; Maia Chaves Filho^a ; ¹ ; Caren Ná ; dia Soares de Sousa^a ; Joã ; o Quevedo^b ; ^c ; ^d ; ^e ; Tatiana Barichello^b ; ^d ; ^e ; ^f ; Hé ; lio Vitoriano Nobre Jú ; nior^g ; David Freitas de Lucena^a
• 关键词：ACTH ; adrenocorticotropic hormone ; BDNF ; Brain-derived neurotrophic factor ; CCL2 ; ; Chemokine (C-C Motif) Ligand 2) ; CMS ; chronic mild stress ; CNS ; central nervous system ; COX 2 ; cyclooxygenase 2 ; GABA ; gamma-aminobutyric acid ; GF ; germ-free ; GLT1 ; glutamate transporter 1 ; HC ; healthy controls ; HPA ; hypothalamic-pituitary-adrenal ; IFN-γ ; gamma interferon ; IgA ; Immunoglobulin A ; IgM ; Immunoglobulin M ; iNOS ; inducible nitric oxide synthase (iNOS) ; JB-1 ; lactobacillus rhamnosus ; LPS ; lipopolysaccha
• 刊名：Journal of Affective Disorders
• 出版年：2017
• 出版时间：15 January 2017
• 年：2017
• 卷：208
• 期：Complete
• 页码：22-32
• 全文大小：935 K
• 卷排序：208

文摘

MDD is related to changes in gut permeability and microbiota composition. Antidepressants present antimicrobial effects. Antimicrobial effect of antidepressants could be related to its effectiveness.