Morphine sulfate concomitantly decreases neuronal differentiation and opioid receptor expression in mouse embryonic stem cells
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- 作者：Sanjay L. Dholakiya ; Angela Aliberti ; Frank A. Barile ; barilef@stjohns.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：bFGF ; basic fibroblast growth factor ; DMEM ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium ; DMEM-ITS ; Dulbecco&rsquo ; s Modified Eagle&rsquo ; s Medium supplemented with insulin ; transferrin ; and selenium ; DOR ; δ-opioid receptor ; EB cells ; embryoid body cells ; EGF ; epidermal growth factor ; GFAP ; glial fibirillary acidic protein ; ITS ; insulin-transferrin-selenium ; KOR ; κ-opioid receptor ; LIF ; leukemia inhibitory factor ; mES cells ; mouse embryonic stem cells ; MS ; morphine sulfate ; MOR ; μ-opioid recep
- 刊名：Toxicology Letters
- 出版年：2016
- 出版时间：15 April 2016
- 年：2016
- 卷：247
- 期：Complete
- 页码：45-55
- 全文大小：2996 K
文摘
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Morphine sulfate treatment decreases neuronal differentiation.
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Morphine has distinct effects on different stages of stem cell/neuronal differentiation (early stage vs. late stage of neuronal development).
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Morphine treatment interferes with neuronal differentiation via MOR activation.