CRL4WDR23-Mediated SLBP Ubiquitylation Ensures Histone Supply during DNA Replication
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- 作者：Mia M.L. Brodersen1 ; mia.li@bc.biol.ethz.ch" class="auth_mail" title="E-mail the corresponding author ; Fabienne Lampert1 ; Christopher A. Barnes1 ; 2 ; Martin Soste1 ; Wojciech Piwko1 ; Matthias Peter1 ; matthias.peter@bc.biol.ethz.ch" class="auth_mail" title="E-mail the corresponding author
- 刊名：Molecular Cell
- 出版年：2016
- 出版时间：19 May 2016
- 年：2016
- 卷：62
- 期：4
- 页码：627-635
- 全文大小：2454 K
文摘
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CRL4WDR23 binds and ubiquitylates SLBP in vitro and in vivo in human cells
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CRL4WDR23-mediated SLBP ubiquitylation promotes histone mRNA processing
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Expression of histones in S phase requires CRL4WDR23
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Lack of CRL4WDR23 activity leads to DNA replication block and impaired growth