Dietary exposure to polybrominated diphenyl ether 47 (BDE-47) inhibits development and alters thyroid hormone-related gene expression in the brain of Xenopus laevis tadpoles

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• 作者：Alexandra T. Yost^a ; Leah M. Thornton^a ; Barney J. Venables^b ; Marlo K. Sellin Jeffries^a ; ^{m.jeffries@tcu.edu}
• 关键词：Polybrominated diphenyl ether ; Metamorphosis ; Development ; Thyroid function ; Endocrine disruption ; Amphibian ; Xenopus ; Gene expression
• 刊名：Environmental Toxicology and Pharmacology
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：48
• 期：Complete
• 页码：237-244
• 全文大小：1166 K
• 卷排序：48

文摘

High-dose BDE-47 hinders Xenopus growth and metamorphosis. Thyroid-related transcriptomic changes were detected in brain, but not tail tissue. Gene expression changes indicated reduced thyroid hormone signaling. BDE-47 altered thyroid-related transcripts associated with neurodevelopment.