Somatosensory map expansion and altered processing of tactile inputs in a mouse model of fragile X syndrome
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- 作者：Konrad Juczewskia ; 1 ; konrad.juczewski@nih.gov" class="auth_mail" title="E-mail the corresponding author ; Helen von Richthofena ; Claudia Bagnib ; c ; f ; Tansu Celikeld ; Gilberto Fisonea ; Patrik Kriegere ; patrik.krieger@rub.de" class="auth_mail" title="E-mail the corresponding author
- 关键词：Fragile X syndrome ; Barrel cortex ; Sensory processing ; Hyperexcitation ; In vivo electrophysiology ; Fmr1 KO ; Whisker system ; Gap-crossing task ; FMRP ; Behavior
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：December 2016
- 年：2016
- 卷：96
- 期：Complete
- 页码：201-215
- 全文大小：1673 K
文摘
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In a mouse model of Fragile X syndrome, we investigated the processing of tactile stimuli in the somatosensory system.
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Fmr1 KO mice have deficits in the encoding of the tactile stimulation frequency.
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They also display an increase in the size of the tactile receptive fields in the somatosensory cortex.
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In a tactile dependent behavioral task, the KO animals reduced the whisker touch-time.
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The cortical deficits could explain the observed behavioral phenotype, suggestive of tactile hypersensitivity.