Determination of kinetic parameters from isothermal calorimetry for interaction processes of pyrimethamine with chitosan derivatives
详细信息 查看全文
- 作者：Eunice F.S. Vieira ; Antonio R. Cestari ; Elaine C.N. Lopes ; Ledjane S. Barreto ; Gilderman S. Lá ; zaro ; Luis E. Almeida
- 关键词：Isothermal calorimetry ; Pyrimethamine ; Adsorption kinetic modeling ; Chitosan
- 刊名：Reactive and Functional Polymers
- 出版年：2007
- 出版时间：September 2007
- 年：2007
- 卷：67
- 期：9
- 页码：820-827
- 全文大小：255 K
文摘
The interaction of the antifolate drug pyrimethamine with chitosan derivatives, namely, chit-GLT (glutaraldehyde cross-linked chitosan gel beads) and chit-Cu (chit-GLT beads treated with copper solution) has been investigated from isothermal calorimetry at 298 and 308 K, being studied in terms of the Avrami and pseudo-first- and second-order kinetic models. The Avrami model provided a high fitting with the experimental data. The results have pointed out the slower kinetic for pyrimethamine sorption on chit-GLT compared to chit-Cu, in agreement with the reaction time obtained from calorimetry.