Effects of antioxidant supplementation on insulin sensitivity, endothelial adhesion molecules, and oxidative stress in normal-weight and overweight young adults
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- 作者：Heather K. Vincent ; Cheryl M. Bourguignon ; Arthur L. Weltman ; Kevin R. Vincent ; Eugene Barrett ; Karen E. Innes ; Ann G. Taylor
- 刊名：Metabolism
- 出版年：2009
- 出版时间：February 2009
- 年：2009
- 卷：58
- 期：2
- 页码：254-262
- 全文大小：275 K
文摘
The objective of the study was to determine whether short-term antioxidant (AOX) supplementation affects insulin sensitivity, endothelial adhesion molecule levels, and oxidative stress in overweight young adults. A randomized, double-blind, controlled study tested the effects of AOXs on measures of insulin sensitivity (homeostasis model assessment [HOMA]) and quantitative insulin sensitivity check index), endothelial adhesion molecules (soluble intercellular adhesion molecule–1, vascular adhesion molecule, and endothelial-leukocyte adhesion molecule–1), adiponectin, and oxidative stress (lipid hydroperoxides) in overweight and normal-weight individuals (N = 48, 18-30 years). Participants received either AOX (vitamin E, 800 IU; vitamin C, 500 mg; β-carotene, 10 mg) or placebo for 8 weeks. The HOMA values were initially higher in the overweight subjects and were lowered with AOX by week 8 (15 % reduction, P = .02). Adiponectin increased in both AOX groups. Soluble intercellular adhesion molecule–1 and endothelial-leukocyte adhesion molecule–1 decreased in overweight AOX-treated groups by 6 % and 13 % , respectively (P < .05). Plasma lipid hydroperoxides were reduced by 0.31 and 0.70 nmol/mL in the normal-weight and overweight AOX-treated groups, respectively, by week 8 (P < .05). Antioxidant supplementation moderately lowers HOMA and endothelial adhesion molecule levels in overweight young adults. A potential mechanism to explain this finding is the reduction in oxidative stress by AOX. Long-term studies are needed to determine whether AOXs are effective in suppressing diabetes or vascular activation over time.