Lipid nanoparticles (SLN, NLC): Overcoming the anatomical and physiological barriers of the eye - Part I - Barriers and determining factors in ocular delivery

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• 作者：E. Sá ; nchez-Ló ; pez^a ; ^b ; M. Espina^a ; ^b ; S. Doktorovova^c ; E.B. Souto^c ; ^d ; M.L. Garcí ; a^a ; ^b ; ^{marisagarcia@ub.edu}
• 关键词：Ocular drug delivery ; Ocular barriers ; Drug transport ; Eye physiology ; Lipid nanoparticles
• 刊名：European Journal of Pharmaceutics and Biopharmaceutics
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：110
• 期：Complete
• 页码：70-75
• 全文大小：828 K
• 卷排序：110

文摘

Ocular drug delivery is still a challenge for researchers in the field of pharmaceutical technology due to anatomical and physiological eye characteristics. The tissue barriers (such as cornea, conjunctiva, blood aqueous barrier, and blood–retinal barrier) limit the access of drugs to their targets. Taking into account the short retention time in the precorneal area of classical ocular dosage forms (e.g. solutions, suspensions or ointments) which are rapidly eliminated by tears and eyelid movement, only less than five percent of the administered drug attains intraocular structures. With the aim to overcome ocular barriers, drug delivery systems, able to increase ocular bioavailability reducing side effects, are recognized as promising alternative. In this review, the main barriers and strategies to increase drug transport in ocular delivery are comprehensively discussed, highlighting the factors involved in ocular transport of SLN and NLC.