The molecular mechanism and effect of cannabinoid-2 receptor agonist on the blood-spinal cord barrier permeability induced by ischemia-reperfusion injury
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- 作者：Ming-chao Yang ; Hang-zhou Zhang ; Zhe Wang ; Fu-li You ; Yan-feng Wang ; wyfdoctor_2015@163.com" class="auth_mail" title="E-mail the corresponding author
- 关键词：Blood&ndash ; spinal cord barrier ; Tight junction ; Cannabinoid-2 receptor ; Caveolin-1 ; Spinal cord ischemia reperfusion injury
- 刊名：Brain Research
- 出版年：2016
- 出版时间：1 April 2016
- 年：2016
- 卷：1636
- 期：Complete
- 页码：81-92
- 全文大小：6436 K
文摘
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JWH-015 could greatly down-regulate the expression of caveolin-1.
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JWH-015 increase the expression of p-PKB and p-FoxO1 protein.
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The effect of JWH-015 could be inhibited by ROS inhibitor.
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The effect of JWH-015 could be inhibited by PI3K inhibitor.