Jmjd3 mediates blood-spinal cord barrier disruption after spinal cord injury by regulating MMP-3 and MMP-9 expressions
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- 作者：Jee Y. Leea ; 1 ; Won H. Nac ; 1 ; Hae Y. Choia ; Kwang H. Leec ; Bong G. Juc ; bgju@sogang.ac.kr" class="auth_mail" title="E-mail the corresponding author ; Tae Y. Yunea ; b ; tyune@khu.ac.kr" class="auth_mail" title="E-mail the corresponding author
- 关键词：AAV ; adeno-associated virus ; BBB ; blood&ndash ; brain barrier ; CNS ; central nervous system ; ChIP ; Chromatin Immunoprecipitation ; Cox ; cyclooxygenase ; GM ; gray matter ; HDAC ; histone deacetylase ; MMP ; matrix metalloprotease ; OGD ; oxygen&ndash ; glucose deprivation ; shRNA ; short hairpin RNA ; SCI ; spinal cord injury ; BSCB ; blood&ndash ; spinal cord barrier ; TJ ; tight junction ; VPA ; valproic acid ; WM ; white matter
- 刊名：Neurobiology of Disease
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：95
- 期：Complete
- 页码：66-81
- 全文大小：2413 K
文摘
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Jmjd3 activates the expression of Mmp-2, -3, and -9 in bEnd.3 cells after hypoxia.
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Silencing Jmjd3 inhibits the expression and activation of MMP-3 and MMP-9 after SCI.
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Silencing Jmjd3 inhibits blood–spinal cord barrier disruption after SCI.
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Silencing Jmjd3 inhibits neuronal death and improves functional recovery after SCI.