- 作者：Enrique Reyes-Muñ ; oz ; M.D. ; M.Sc.a ; dr.enriquereyes@gmail.com ; Guillermo Castellanos-Barroso ; M.D.b ; Brenda Y. Ramí ; rez-Eugenio ; M.D.b ; Carlos Ortega-Gonzá ; lez ; M.D.a ; Adalberto Parra ; M.D.a ; Alfredo Castillo-Mora ; M.D.a ; Julio F. De la Jara-Dí ; az ; M.D.b
- 关键词：Polycystic ovary syndrome ; infertility ; gestational diabetes mellitus ; perinatal outcomes
- 刊名：Fertility and Sterility
- 出版年：2012
- 出版时间：June, 2012
- 年：2012
- 卷：97
- 期：6
- 页码：1467-1471
- 全文大小：101 K
Objective
To study the incidence of gestational diabetes mellitus (GDM) in Mexican women with a history of infertility and polycystic ovary syndrome (PCOS) compared with women without PCOS matched by age, pregestational body mass index (BMI), and parity.Design
Historic cohort study.
Setting
Level three medical institution.
Patient(s)
Group 1 (n = 52), women with a history of infertility and PCOS, and group 2 (n = 52), women without PCOS. Inclusion criteria were singleton pregnancy with ¡Ü13 weeks of gestation. Exclusion criteria were pregestational diabetes mellitus and/or concomitant diseases.
Intervention(s)
Diagnosis of GDM was based on a 3-hour, 100-g oral glucose tolerance test (GTT) performed during the second trimester.
Main Outcome Measure(s)
Incidence and relative risk (RR) for GDM.
Result(s)
The incidence of GDM was 26.9 % and 9.6 % for groups 1 and 2, respectively (RR = 2.8; 95 % confidence interval 1.08-7.2). No other between-group differences were observed in the incidence of miscarriage, preterm birth, premature rupture of membranes, preeclampsia, stillbirth, fetal malformations, or small or large for gestational age newborns.
Conclusion(s)
Pregnant Mexican women with a history of infertility and PCOS are at increased risk for developing GDM. This risk should be considered beginning early in the second trimester for a timely intervention and to improve the maternal-fetal prognosis.