- 作者：Jose Murillo B. Netto ; Carlos Eduardo P.F. Ferrarez ; Anucha Andrade Schindler Leal ; Silvio Tucci Jr. ; Carlos Augusto Gomes ; Ubirajara Barroso Jr.
- 关键词：Hypospadias ; Testosterone ; Human chorionic gonadotropin ; Dihydrotestosterone ; Hormone therapy ; Children
- 刊名：Journal of Pediatric Urology
- 出版年：December, 2013
- 年：2013
- 卷：9
- 期：6
- 页码：971-979
- 全文大小：200 K
To try to elucidate this matter, an electronic survey of the databases PubMed and Cochrane Central Library was conducted, limited to articles in English published since 1980. Search strategy identified 14 clinical trials that matched the inclusion criteria. Analysis was made in terms of study design, classification of hypospadias, association with chordee and cryptorchidism, type of hormone, route of application, dose and duration of treatment, penile length before and after hormone therapy, glans circumference before and after hormone therapy, adverse effects, and surgical complications.
From the trials evaluated it was not possible to determine the ideal neoadjuvant treatment. A preference for use of testosterone was observed. Intramuscular administration seems to have fewer adverse effects than topical treatment. Side effects were seldom described, and treated patients were not followed on a long-term basis. The scarcity of randomized and controlled clinical trials regarding the topic impairs the establishment of a protocol.
In conclusion, although preoperative hormone therapy is currently used before hypospadias surgery, its real benefit in terms of improvement of the penis and surgical results has not been defined.