Effects of nucleus accumbens amphetamine administration on performance in a delay discounting task

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• 作者：Caitlin A. Orsini^a ; ^{orsini@ufl.edu} ; Marci R. Mitchell^b ; Sara C. Heshmati^a ; Kristy G. Shimp^a ; Megan S. Spurrell^a ; Jennifer L. Bizon^a ; ^c ; ^e ; Barry Setlow^a ; ^c ; ^d ; ^e ; ^{setlow@ufl.edu}
• 关键词：Impulsive choice ; Delay discounting ; Intertemporal choice ; Nucleus accumbens ; Amphetamine ; Dopamine
• 刊名：Behavioural Brain Research
• 出版年：2017
• 出版时间：15 March 2017
• 年：2017
• 卷：321
• 期：Complete
• 页码：130-136
• 全文大小：970 K
• 卷排序：321

文摘

Chronic cocaine can increase both impulsive choice and nucleus accumbens (NAc) dopamine (DA) release. Thus, enhanced NAc DA release could mediate chronic cocaine-induced impulsive choice. Intra-NAc amphetamine increased choice of large rewards in an ascending delay discounting task. Intra-NAc amphetamine decreased choice of the large rewards in a descending delay discounting task. NAc DA may be important for flexible decision making.