Improved Ribosome-Footprint and mRNA Measurements Provide Insights into Dynamics and Regulation of Yeast Translation
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- 作者：David E. Weinberg1 ; 8 ; david.weinberg@ucsf.edu" class="auth_mail" title="E-mail the corresponding author ; Premal Shah2 ; 8 ; 9 ; Stephen W. Eichhorn3 ; 4 ; 5 ; Jeffrey A. Hussmann6 ; 7 ; Joshua B. Plotkin2 ; David P. Bartel3 ; 4 ; 5
- 刊名：Cell Reports
- 出版年：2016
- 出版时间：23 February 2016
- 年：2016
- 卷：14
- 期：7
- 页码：1787-1799
- 全文大小：49975 K
文摘
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Ribosome dwell times are typically longer at codons for less abundant tRNAs
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The first 200 codons tend to be translated more slowly, regardless of codon choice
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Accurate yeast mRNA abundances reveal a narrow range of translational efficiencies
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A statistical model explains much of the variation in initiation efficiencies