2-(N-Benzyl-N-phenylsulfonamido)alkyl amide derivatives as ¦Ã-secretase inhibitors
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- 作者：Michael F. Parker ; Donna M. Barten ; Carl P. Bergstrom ; Joanne J. Bronson ; Jason A. Corsa ; Michael F. Dee ; Yonghua Gai ; Valerie L. Guss ; Mendi A. Higgins ; Daniel J. Keavy ; Alice Loo ; Robert A. Mate ; Larry R. Marcin ; Katharine E. McElhone ; Craig T. Polson ; Susan B. Roberts ; John E. Macor
- 关键词：Alzheimer&rsquo ; s ; Gamma secretase inhitors ; Phenyl sulfonamides
- 刊名：Bioorganic and Medicinal Chemistry Letters
- 出版年：2012
- 出版时间：15 November, 2012
- 年：2012
- 卷：22
- 期：22
- 页码：6828-6831
- 全文大小：1454 K
文摘
A series of (N-benzyl-N-phenylsulfonamido)alkyl amides were developed from classic and parallel synthesis strategies. Compounds with good in vitro and in vivo ¦Ã-secretase activity were identified and described.