Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers

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• 作者：Vinay Kumar Singh ; Vaibhav Mishra ; Sriniwas Tiwari ; Tanvir Khaliq ; Manoj Kumar Barthwal ; Haushila Prasad P ; ey ; Gautam Palit ; Tadigoppula Narender
• 关键词：Peganum harmala ; Peganine hydrochloride ; Proton pump ; Gastric ulcer ; Gastric acid secretion
• 刊名：Phytomedicine
• 出版年：2013
• 出版时间：15 October, 2013
• 年：2013
• 卷：20
• 期：13
• 页码：1180-1185
• 全文大小：1434 K

文摘

Gastroprotective mechanism of peganine hydrochloride isolated from Peganum harmala seeds was investigated. Peganine hydrochloride was evaluated against cold restraint (CRU), aspirin (AS), alcohol (AL) and pyloric ligation (PL) induced gastric ulcer models in rats. Potential anti-ulcer activity of peganine was observed against CRU (50.0 % ), AS (58.5 % ), AL (89.41 % ) and PL (62.50 % ) induced ulcer models. The reference drug omeprazole (10 mg/kg, p.o.) showed 77.45 % protection against CRU, 49.97 % against AS and 69.42 % against PL model. Sucralfate, another reference drug (500 mg/kg, p.o.) showed 62.50 % protection in AL induced ulcer model. Peganine significantly reduced free acidity (33.38 % ), total acidity (38.09 % ) and upregulated mucin secretion by 67.91 % , respectively. Further, peagnine significantly inhibited H⁺ K⁺-ATPase activity in vitro with IC₅₀ of 73.47 ¦Ìg/ml as compared to the IC₅₀ value of omeprazole (30.24 ¦Ìg/ml) confirming its anti-secretory activity.