Arbortristoside-A and 7-O-trans-cinnamoyl-6¦Â-hydroxyloganin isolated from Nyctanthes arbortristis possess anti-ulcerogenic and ulcer-healing properties

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• 作者：Vaibhav Mishra ; Astha Shukla ; Sukanya P ; eti ; Manoj Kumar Barthwal ; Haushila Prasad P ; ey ; Gautam Palit ; Tadigoppula Narender
• 关键词：Nyctanthes arbortristis ; Arbortristoside-A ; 7-O-Trans-cinnamoyl6¦Â-hydroxyloganin ; Gastric ulcer ; Proton pump ; PGE2
• 刊名：Phytomedicine
• 出版年：2013
• 出版时间：15 September, 2013
• 年：2013
• 卷：20
• 期：12
• 页码：1055-1063
• 全文大小：2745 K

文摘

Nyctanthes arbortristis Linn (Oleaceae) is widely distributed in sub-Himalayan regions and southwards to Godavari, India commonly known as Harsingar and Night Jasmine. In continuation of our drug discovery program on Indian medicinal plants, we isolated arbortristoside-A (AT) and 7-O-trans-cinnamoyl-6¦Â-hydroxyloganin (6-HL) from the seeds of N. arbortristis. AT and 6-HL exhibited anti ulcer activity in experimentally induced ulcer models including cold restraint stress (CRU), alcohol (AL), pylorus ligation-induced gastric ulcer (PL) models and they also showed ulcer healing effect in chronic acetic acid-induced ulcer model (AC).