Hematopoietic, Mesenchymal, and Immune Cells Are More Enhanced in Bone Marrow than in Peripheral Blood from Granulocyte Colony-Stimulating Factor Primed Healthy Donors
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- 作者：Lidia De Felice1 ; lidia.defelice@uniroma1.it" class="auth_mail" title="E-mail the corresponding author ; Francesca Agostini2 ; Carmela Suriano2 ; Daniela Fraboni2 ; Chiara Gregorj3 ; Maria Cristina Tirindelli3 ; Alessandra Picardi2 ; Stella Santarone4 ; Fabio Di Piazza2 ; Paolo Di Bartolomeo4 ; William Arcese2
- 关键词：Granulocyte colony-stimulating factor ; Hematopoietic stem cells ; Mesenchymal stem cells ; Immune modulation ; Haploidentical transplant
- 刊名：Biology of Blood and Marrow Transplantation
- 出版年：2016
- 出版时间：October 2016
- 年：2016
- 卷：22
- 期：10
- 页码：1758-1764
- 全文大小：1317 K
文摘
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Early CD34+CD38− cell fraction is highly increased in G-BM.
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A striking rise of the mesenchymal progenitors is detected in BM after in vivo G-CSF priming.
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The effect of G-CSF priming on immune cells is more pronounced in BM than in PB.
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Regulatory T cells increase only in G-BM.