The Italian multicentre dosimetric study for lesion dosimetry in ²²³Ra therapy of bone metastases: Calibration protocol of gamma cameras and patient eligibility criteria

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• 作者：Massimiliano Pacilio^a ; ^{mpacilio@scamilloforlanini.rm.it} ; Bartolomeo Cassano^b ; Carlo Chiesa^c ; Stefano Giancola^d ; Mahila Ferrari^e ; Cinzia Pettinato^f ; Ernesto Amato^g ; Federica Fioroni^h ; Leda Lorenzonⁱ ; Rosanna Pellegrini^j ; Elisabetta Di Castro^k ; Roberto Pani^l ; Marta Cremonesi^m
• 关键词：Bone metastases ; 223Ra-dichloride ; Radionuclide therapy ; Dosimetry
• 刊名：Physica Medica
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：32
• 期：12
• 页码：1731-1737
• 全文大小：685 K
• 卷排序：32

文摘

Gamma camera calibration procedures for dosimetry in 223Ra therapy are examined. Criteria for patient eligibility in bone lesion dosimetric studies are analysed. Differences in experimental setups may affect calibrations and activity estimations. Transmission curves should be measured for several source sizes. Lesion contrast on 99mTc-MDP images is predictive for visibility on 223Ra images.