Physical and chemical limitations to preparation of beta radioactive stents by direct neutron activation

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• 作者：Petelenz ; Barbara ; Rajchel ; Boguslaw ; Bilski ; Pawel ; Misiak ; Ryszard ; Bartyzel ; Miroslaw ; Wilczek ; Krzysztof ; et. al.
• 关键词：Beta particles ; Ion implantation ; Intravascular brachytherapy ; Neutron activations ; ³²P ; Stents
• 刊名：Biomaterials
• 出版年：2003
• 出版时间：February, 2003
• 年：2003
• 卷：24
• 期：3
• 页码：427-433
• 全文大小：226 K

文摘

Pure beta emitters are the sources of choice for intracoronary irradiations in restenosis prevention. In this work we reconsidered preparation of low activity ³²P sources by ion-implantation of stable ³¹P into highly biocompatible pure titanium stents, followed by neutron activation. Gamma-spectrometrical analysis has shown that during activations with high thermal neutrons flux production of gamma-active long-lived contaminants is much beyond the dosimetrically acceptable limit, mainly due to the competing (n,p) reactions induced by the fast neutrons on isotopes of the bulk stent material, and to a lesser extent due to (n,γ) reactions on chemical impurities. A potential applicability of this method for obtaining alternative beta radioactive stents is discussed.