Striking medium effects on the kinetics of decomposition of macrocyclic Cu²⁺ complexes: Additional considerations to be taken when designing Copper-64 radiopharmaceuticals

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• 作者：Manuel G. Basallote ; Carmen E. Castillo ; M. Angeles Má ; ñ ; ez ; Př ; emysl Lubal ; Manuel Martí ; nez ; Carlos Rodrí ; guez ; Jakub Vaně ; k
• 关键词：Decomposition of copper complexes ; Kinetics ; Electrolyte media ; Copper-64 radiopharmaceuticals
• 刊名：Inorganic Chemistry Communications
• 出版年：2010
• 出版时间：November 2010
• 年：2010
• 卷：13
• 期：11
• 页码：1272-1274
• 全文大小：259 K

文摘

The kinetics of decomposition of a macrocyclic Cu²⁺ complex is strongly dependent on the anions in solution. In particular, chloride anions accelerate significantly the decomposition process, even out of the stopped-flow time scale. Given the different Cl⁻ concentrations in biological media, the possibility of changes in the decomposition kinetics must be considered when designing ⁶⁴Cu radiopharmaceuticals.