Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis

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• 作者：Annette Becker¹ ; ⁵ ; Basant Kumar Thakur¹ ; ³ ; ⁵ ; Joshua Mitchell Weiss¹ ; Han Sang Kim¹ ; ⁴ ; Hé ; ctor Peinado¹ ; ² ; ^{hpeinado@cnio.es} ; David Lyden¹ ; ^{dcl2001@med.cornell.edu}
• 关键词：exosomes ; extracellular vesicles ; microvesicles ; metastasis ; cancer ; intercellular communication ; pre-metastatic niche
• 刊名：Cancer Cell
• 出版年：2016
• 出版时间：12 December 2016
• 年：2016
• 卷：30
• 期：6
• 页码：836-848
• 全文大小：3446 K
• 卷排序：30

文摘

Tumor-secreted extracellular vesicles (EVs) are critical mediators of intercellular communication between tumor cells and stromal cells in local and distant microenvironments. Accordingly, EVs play an essential role in both primary tumor growth and metastatic evolution. EVs orchestrate multiple systemic pathophysiological processes, such as coagulation, vascular leakiness, and reprogramming of stromal recipient cells to support pre-metastatic niche formation and subsequent metastasis. Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.