Laser irradiation to produce amorphous pharmaceuticals

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• 作者：Varin Titapiwatanakun ; Junlathip Tankul ; Abdul W. Basit ; Simon Gaisford ; ^{s.gaisford@ucl.ac.uk" class="auth_mail" title="E-mail the corresponding author}
• 关键词：CO2 laser ; Phase-transformation ; Indomethacin ; Paracetamol ; PVP K30 ; Amorphous ; Solid amorphous dispersion
• 刊名：International Journal of Pharmaceutics
• 出版年：2016
• 出版时间：30 November 2016
• 年：2016
• 卷：514
• 期：1
• 页码：282-289
• 全文大小：2497 K

文摘

Using a high-power CO₂ laser to irradiate powder beds, it was possible to induce phase transformation to the amorphous state. Irradiation of a model drug, indometacin, resulted in formation of a glass. Varying the settings of the laser (power and raster speed) was shown to change the physicochemical properties of the glasses produced and all irradiated glasses were found to be more stable than a reference glass produced by melt-quenching. Irradiation of a powder blend of paracetamol and polyvinylpyrrolidone K30 was found to produce a solid amorphous dispersion. The results suggest that laser-irradiation might be a useful method for making amorphous pharmaceuticals.