Periodic acceleration (pGz) CPR in a swine model of asphyxia induced cardiac arrest: Short-term hemodynamic comparisons

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• 作者：Jose A. Adams ; Jorge A. Bassuk ; Jaqueline Arias ; Heng Wu ; Vinod Jorapur ; Gervasio A. Lamas ; Paul Kurlansky
• 关键词：Periodic acceleration ; Hypoxia ; Asphyxia ; Cardiopulmonary resuscitation ; Nitric oxide ; Prostaglandins ; Echocardiography ; Myocardial stunning ; Ischemia reperfusion
• 刊名：Resuscitation
• 出版年：2008
• 出版时间：April 2008
• 年：2008
• 卷：77
• 期：1
• 页码：132-138
• 全文大小：457 K

文摘

Asphyxia is one of the most common causes of pediatric cardiac arrest, and becoming a more frequently recognized cause in adults. Periodic acceleration (pGz) is a novel method of cardiopulmonary resuscitation (CPR). pGz is achieved by rapid motion of the supine body headward–footward that generates adequate perfusion and ventilation during cardiac arrest. In a swine ventricular fibrillation cardiac arrest model, pGz produced a higher return of spontaneous circulation (ROSC), superior neurological outcome, less echocardiography evidence of post resuscitation myocardial stunning, and decreased indices of tissue injury. In contrast to standard chest compression CPR, pGz does not produce rib fractures. We investigated the feasibility of pGz in severe asphyxia cardiac arrest and assessed whether beneficial effects seen in the VF model of cardiac arrest could be realized.