The influence of insulin-like Growth Factor-1-Receptor expression and endocrine treatment on clinical outcome of postmenopausal hormone receptor positive breast cancer patients: A Dutch TEAM substudy analysis
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- 作者：Charla C. Engelsa ; 1 ; Nienke A. de Glasa ; b ; 1 ; Anita Sajeta ; Esther Bastiaanneta ; b ; Vincent T.H.B.M. Smitc ; Peter J.K. Kuppena ; Caroline Seynaeved ; Cornelis J.H. van de Veldea ; Gerrit Jan Liefersa ; g.j.liefers@lumc.nl" class="auth_mail" title="E-mail the corresponding author
- 关键词：Breast cancer ; Clinical outcome ; IGF1 receptor ; Hormone receptor ; Endocrine treatment ; Metformin
- 刊名：Molecular Oncology
- 出版年：2016
- 出版时间：April 2016
- 年：2016
- 卷：10
- 期：4
- 页码：509-516
- 全文大小：832 K
文摘
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Breast tumor tissue sections from Dutch TEAM patients were immunohistochemically stained for IGF1R status.
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Part of this cohort was using metformin because of Diabetes type 2.
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Breast cancer patients on exemestane harboring high IGF1R tumor expression had significantly less breast cancer relapse.
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The addition of metformin to exemestane treatment resulted in improved efficacy.
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Dual blockade of insulin- and estrogen-related growth pathway may improve outcome in selective breast cancer patients.