Relationship between natural and heme-mediated antibody polyreactivity
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- 作者：Maya Hadzhievaa ; Tchavdar Vassileva ; Jagadeesh Bayryb ; c ; d ; Srinivas Kaverib ; c ; d ; Sé ; bastien Lacroix-Desmazesb ; c ; d ; Jordan D. Dimitrovb ; c ; d ; jordan.dimitrov@crc.jussieu.fr" class="auth_mail" title="E-mail the corresponding author
- 关键词：Immunoglobulins ; Antibody polyreactivity ; Heme ; Thermodynamics
- 刊名：Biochemical and Biophysical Research Communications
- 出版年：2016
- 出版时间：25 March 2016
- 年：2016
- 卷：472
- 期：1
- 页码：281-286
- 全文大小：787 K
文摘
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Exposure of certain monoclonal IgE antibodies to heme results in gain of antigen binding polyreactivity.
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Natural polyreactivity of antibodies is dispensable for acquisition of polyreactivity through interaction with heme.
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Heme-induced monoclonal IgE antibodies differ in their thermodynamic mechanisms of antigen recognition.