Melatonin and the newborn brain

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• 作者：Marina Colella ; Valé ; rie Biran ; Olivier Baud ; ^{olivier.baud@aphp.fr" class="auth_mail" title="E-mail the corresponding author}
• 关键词：Brain injury ; Preterm birth ; Melatonin ; Translational research ; Neuroprotection
• 刊名：Early Human Development
• 出版年：2016
• 出版时间：November 2016
• 年：2016
• 卷：102
• 期：Complete
• 页码：1-3
• 全文大小：192 K

文摘

Brain injury related to preterm birth and neonatal asphyxia is a leading cause of childhood neuromotor and cognitive disabilities. Unfortunately, the strategies to prevent perinatal brain damages remain limited. Among the candidate molecules, melatonin appears to be one of the most promising agents for its antioxidant and neuromodulatory action. Robust preclinical evidences and few clinical studies have suggested a neuroprotective benefit conferred by neonatal exposure to melatonin. This review recapitulates current basic research, safety and pharmacokinetic data and ongoing clinical trials on the use of melatonin as a neuroprotective agent in the newborn.