Plerixafor use in patients with previous mobilization failure: A multicenter experience

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• 作者：Emre Tekg¨¹nd¨¹z ; Fevzi Altunta? ; Serdar ??vg?n ; ?ahika Zeynep Ak? ; Ayhan D?nmez ; Pervin Top?uo?lu ; Rah?an Y?ld?r?m ; Nuran Ahu Baysal ; Erol Ayy?ld?z ; Meltem Kurt Y¨¹ksel ; ?smail Sar? ; Murat Tombulo?lu ; Ali ¨¹nal ; Osman ?lhan
• 关键词：Plerixafor ; Stem cell mobilization ; Mobilization failure ; Chemotherapy
• 刊名：Transfusion and Apheresis Science
• 出版年：2012
• 出版时间：August, 2012
• 年：2012
• 卷：47
• 期：1
• 页码：77-80
• 全文大小：153 K

文摘

Plerixafor in conjunction with G-CSF (G-P) is an effective strategy for hematopoietic stem cell mobilization in patients with previously failed mobilization attempt. Here we report our results with G-P among patients with at least one mobilization failure with G-CSF alone (G) or G-CSF plus chemotherapy (G-C). The study included 20 consecutive patients with lymphoma and myeloma from five centers. In 14 (70 % ) patients, a minimum of 2 ¡Á 10⁶/kg CD34+ stem cells were collected and 16 out of 20 patients (80 % ) were able to proceed to ASCT. Our study indicates that plerixafor can safely rescue patients with a history of mobilization failure.