A vertex set S of a graph G is a dominating set if each vertex of G either belongs to S or is adjacent to a vertex in S. The domination number γ(G) of G is the minimum cardinality of S as S varies over all dominating sets of G. It is known that , where diam(G) denotes the diameter of G. Define Cr as the largest constant such that γ(G)≥Cr∑1≤i<j≤rd(xi,xj) for any bb941db97e6" title="Click to view the MathML source">r vertices of an arbitrary connected graph G; then in this view. The main result of this paper is that for r≥3. It immediately follows that , where μ(G) and W(G) are respectively the average distance and the Wiener index of G of order n. As an application of our main result, we prove a conjecture of DeLaViña et al. that , where eccG(B) denotes the eccentricity of the boundary of an arbitrary connected graph G.