Altered ultrastructure, density and cathepsin K expression in bone of female muscarinic acetylcholine receptor M3 knockout mice
详细信息 查看全文
- 作者：Katrin Susanne Lipsa ; Katrin.S.Lips@chiru.med.uni-giessen.de" class="auth_mail" title="E-mail the corresponding author ; Mathias Kneffela ; Fee Willscheida ; Frank Martin Mathiesb ; Marian Kampschultec ; d ; Sonja Hartmanna ; Imke Panzera ; Lutz Dü ; rselene ; Christian Heissa ; f ; Vivien Kauschkea
- 关键词：ALP ; alkaline phosphatase ; BCIP/NBT ; 5-bromo-4-chloro-3-indolyphosphate/nitro blue tetrazolium chloride ; BMC ; bone mineral content ; BMD ; bone mineral density ; BS/TV ; relative bone surface ; BV/TV ; relative bone volume ; CaHA ; calcium hydroxyapatite ; CtsK ; cathepsin-K ; DXA ; dual-energy X-ray absorptiometry ; El ; bending stiffness ; FU ; ultimate bending load ; HE ; hematoxylin-eosin ; L ; lumbar vertebrae ; mAChR ; muscarinic acetylcholine receptor ; M3R ; muscarinic acetylcholine receptor subtype M3 ; M3R-KO
- 刊名：International Immunopharmacology
- 出版年：2015
- 出版时间：November 2015
- 年：2015
- 卷：29
- 期：1
- 页码：201-207
- 全文大小：1516 K
文摘
- •
Cathepsin K mRNA expression was increased in M3R-KO compared to WT.
- •
Biomechanical strength, cortical thickness, and mineral density were reduced.
- •
Ultrastructure of bone cells was altered in M3R-KO compared to WT.