EZH2 and BCL6 Cooperate to Assemble CBX8-BCOR Complex to Repress Bivalent Promoters, Mediate Germinal Center Formation and Lymphomagenesis
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- 作者：Wendy Bé ; guelin1 ; Matt Teater1 ; 2 ; Micah D. Gearhart3 ; Marí ; a Teresa Calvo Ferná ; ndez1 ; Rebecca L. Goldstein1 ; Mariano G. Cá ; rdenas1 ; Katerina Hatzi1 ; Monica Rosen1 ; Hao Shen1 ; Connie M. Corcoran3 ; Michelle Y. Hamline3 ; 7 ; Randy D. Gascoyne4 ; Ross L. Levine5 ; Omar Abdel-Wahab5 ; Jonathan D. Licht6 ; Rita Shaknovich1 ; Olivier Elemento2 ; Vivian J. Bardwell3 ; bardw001@umn.edu" class="auth_mail" title="E-mail the corresponding author ; Ari M. Melnick1 ; amm2014@med.cornell.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cancer Cell
- 出版年：2016
- 出版时间：8 August 2016
- 年：2016
- 卷：30
- 期：2
- 页码：197-213
- 全文大小：7593 K
文摘
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EZH2 and BCL6 mediate combinatorial tethering of non-canonical PRC1-BCOR complex
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CBX8 binding to bivalent promoters enables GC B cell-specific PRC1-BCOR recruitment
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BCOR tethering by EZH2 activity and BCL6 is required for GC and drives GC hyperplasia
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Combinatorial targeting of EZH2 and BCL6 yields enhanced anti-lymphoma effect