KDM2B Recruitment of the Polycomb Group Complex, PRC1.1, Requires Cooperation between PCGF1 and BCORL1
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- 作者：Sarah J. Wong1 ; Micah D. Gearhart2 ; Alexander B. Taylor1 ; David R. Nanyes1 ; Daniel J. Ha1 ; Angela K. Robinson1 ; Jason A. Artigas3 ; Oliver J. Lee3 ; Borries Demeler1 ; P. John Hart1 ; 4 ; Vivian J. Bardwell2 ; Chongwoo A. Kim3 ; 5 ; ckim@midwestern.edu" class="auth_mail" title="E-mail the corresponding author
- 刊名：Structure
- 出版年：2016
- 出版时间：4 October 2016
- 年：2016
- 卷：24
- 期：10
- 页码：1795-1801
- 全文大小：1788 K
文摘
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In vitro assembly of PRC1.1 core is achieved by combining two separate subcomplexes
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PCGF1/BCORL1 cooperation is required for association with KDM2B/SKP1
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PCGF1 RAWUL domain binding selectivity is critical for assembling distinct PRC1s
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Structure provides foundation for assessing BCOR PUFD ITDs in brain and kidney tumors