Casiopeina III-Ea, a copper-containing small molecule, inhibits the in vitro growth of primitive hematopoietic cells from chronic myeloid leukemia

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• 作者：Antonieta Chavez-Gonzalez^a ; ^{acgtony@yahoo.com.mx} ; Sandra Centeno-Llanos^a ; ¹ ; Dafne Moreno-Lorenzana^a ; ¹ ; Miguel Angel Sandoval-Esquivel^a ; Socrates Aviles-Vazquez^a ; Marí ; a Elena Bravo-Gomez^b ; Lena Ruiz-Azuara^c ; Manuel Ayala-Sanchez^d ; Hector Torres-Martinez^e ; Hector Mayani^a ; ^{hmayaniv@prodigy.net.mx}
• 关键词：Chronic myeloid leukemia ; Leukemic stem cells elimination ; Casiopeinas
• 刊名：Leukemia Research
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：52
• 期：Complete
• 页码：8-19
• 全文大小：3057 K
• 卷排序：52

文摘

Chronic Myeloid Leukemia is initiated and sustained by BCR-ABL+ leukemia stem cells. Quiescent Leukemic Stem Cells are insensitive to BCR-ABL Tyrosine Kinase Inhibitors. Casiopeinas are novel small molecules with anticancer activity. Casiopeina III-Ea possesses antileukemic activity in vitro with minimal effects on normal cells.