- 作者：Beatriz Vera-Sirera ; Jos¨¦ Delhom-Valero ; Ma Carmen Baquero Ru¨ªz de la Hermosa ; Francisco Vera-Sempere
- 关键词：Ú ; lcera eosinofí ; lica ; Granuloma ulcerativo traumá ; tico con eosinofí ; lia estromal ; Histopatologí ; a ; Inmunohistoquí ; mia
- 刊名：Revista Espa?ola de Cirug¨ªa Oral y Maxilofacial
- 出版年：2013
- 出版时间：July-September, 2013
- 年：2013
- 卷：35
- 期：3
- 页码：128-132
- 全文大小：1622 K
Eosinophilic ulcer, also know as traumatic ulcerative granuloma with stromal eosinophilia, is a rare and benign ulcerative lesion of oral mucosa that has a persistent progression, often requiring a differential clinical diagnosis. The diagnosis is only established from histopathological studies, which frequently show morphological features that may be suggestive of a lymphoproliferative process, resulting in a controversial pathogenesis that is still not clarified today.
We report the clinical and pathological observations of an eosinophilic ulcer affecting a woman 76 year-old woman. A biopsy was performed twice on a 2.5 cm diameter ulcer affecting the lingual edge. After a clinical follow-up of 5 months, a self-limiting course with the production of a scar was verified. She has currently been scheduled for an extended 24-month clinical follow-up. The morphological and immunohistochemical features found in the biopsy study are presented, and the pathogenesis hypothesis of this uncommon ulcerative lesion is discussed.