• 作者：Beatriz Vera-Sirera^a ; Julia Guarí ; n^b ; Cecilia Ló ; pez-Valdivia^b ; Enrique Jimé ; nez^b ; Mª ; Carmen Baquero Ruí ; z de la Hermosa^c ; Francisco Vera-Sempere^b ; ^d ; ^{fco.jose.vera@uv.es}
• 关键词：Quistes maxilares ; Tumor odontogé ; nico queratoquí ; stico ; Quiste odontogé ; nico ortoquerató ; sico ; Inmunohistoquí ; mia ; Diagnó ; stico diferencial
• 刊名：Revista Espa?ola de Cirug¨ªa Oral y Maxilofacial
• 出版年：2011
• 出版时间：October-December 2011
• 年：2011
• 卷：33
• 期：4
• 页码：142-149
• 全文大小：441 K

Objectives

Maxillary cystic lesions with keratinization are controversial lesions that are clinically relevant due to the prognostic implication of the so-called keratocystic odontogenic tumor (KOT). The aim of this study was to assess the usefulness of immunohistochemistry in the identification of KOTs.

Material and methods

Retrospective study of all maxillary cystic lesions exhibiting keratinization diagnosed over a 4-year period in one hospital center. Immunohistochemical study using a panel of five antibodies (Ki67, Bcl-2, p53, CK19, D2-40) was performed.

Results

Of a total of 410 maxillary cystic lesions, 22 cases (5.36 % ) showing morphological features of internal keratinization were selected. Using WHO-2005 histological criteria, 15 KOTs and 4 orthokeratotic odontogenic cysts (OOC) were diagnosed, as well as 3 cases with hybrid morphological characteristics. Immunohistochemical results accurately differentiated between KOT and OOC and allowed the hybrid forms to be correctly identified.

Conclusions

Immunohistochemical analysis with a panel of five antibodies allows an accurate diagnosis of maxillary cystic lesions with keratinization, enabling the differentiation between KOT and OOC and the correct identification of cases of hybrid morphological characteristics.