Maxillary growth in a congenital cleft palate canine model for surgical research

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• 作者：Irene Paradas-Lara ; Inmaculada Casado-G贸mez ; Conchita Mart铆n ; Elena Mart铆nez-Sanz ; Yamila L贸pez-Gordillo ; Pablo Gonz谩lez ; Cruz Rodr铆guez-Bobada ; Manuel Chamorro ; Pablo Arias ; Estela Maldonado ; Ricardo Ortega ; Beatriz Berenguer ; Concepci贸n Mart铆nez-脕lvarez
• 关键词：Congenital cleft palate ; Dog ; Surgical research ; Maxillofacial growth
• 刊名：Journal of Cranio-Maxillofacial Surgery
• 出版年：January, 2014
• 年：2014
• 卷：42
• 期：1
• 页码：13-21
• 全文大小：1312 K

文摘

We have recently presented the Old Spanish Pointer dog, with a 15-20% spontaneous congenital cleft palate rate, as a unique experimental model of this disease. This study aimed to describe the cleft palate of these dogs for surgical research purposes and to determine whether congenital cleft palate influences maxillofacial growth.

Seven newborn Old Spanish Pointer dogs of both sexes, comprising a cleft palate group (n聽=聽4) and a normal palate group (n聽=聽3), were fed using the same technique. Macroscopic photographs and plaster casts from the palate, lateral radiographs and computer tomograms of the skull were taken sequentially over 41 weeks, starting at week 5.

The cleft morphology, the size and the tissue characteristics in these dogs resembled the human cleft better than current available animal models. During growth, the cleft width varies. Most of the transverse and longitudinal measures of the palate were statistically lower in the cleft palate group. The cleft palate group showed hypoplasia of the naso-maxillary complex.

This model of congenital cleft palate seems suitable for surgical research purposes. A reduced maxillofacial pre- and post-natal development is associated to the congenital cleft palate in the Old Spanish Pointer dog.