Low Skeletal Muscle Mass and Risk of Functional Decline in Elderly Community-Dwelling Women: The Prospective EPIDOS Study

详细信息    查看全文

• 作者：Isabelle Amigues ; MD^a ; ^b ; Anne-Marie Schott ; MD ; PhD^a ; Mohamed Amine ; MD ; MPH^c ; Bé ; nedicte Gelas-Dore ; MPH^a ; Kalaivani Veerabudun ; MPH^d ; ^e ; Elena Paillaud ; MD ; PhD^f ; ^g ; Olivier Beauchet ; MD ; PhD^g ; Yves Rolland ; MD ; PhD^h ; Florence Canouï ; Poitrine ; MD ; PhD^a ; ^d ; ^e ; ^{florence.canoui-poitrine@hmn.aphp.fr} ; Marc Bonnefoy ; MD ; PhDⁱ
• 关键词：Sarcopenia ; aged adults ; elderly ; anthropometry ; body mass index ; obesity ; female ; longitudinal study ; geriatric assessment ; epidemiology
• 刊名：Journal of the American Medical Directors Association
• 出版年：2013
• 出版时间：May, 2013
• 年：2013
• 卷：14
• 期：5
• 页码：352-357
• 全文大小：189 K

文摘

Objectives

To assess relationships between low skeletal muscle mass (SMM) and functional decline in community-dwelling elderly women.

Design

Secondary analysis of data from EPIDOS, a French prospective observational multicenter cohort study of osteoporosis epidemiology.

Setting

One center in France between 1992 and?1994.

Participants

Women aged 75 years or older without disability and with available baseline SMM measurements.

Measurements

SMM was assessed using dual-energy X-ray absorptiometry and functional decline was defined as loss of at least one Instrumental Activity of Daily Living component. Associations linking low SMM to functional decline were estimated using the Cox proportional hazards model.

Results

Of 975 women followed for 4 years, 452 (46.4 % ) experienced functional decline. Factors independently associated with functional decline were decreased SMM (adjusted hazard ratio [aHR] per SD decrease, 1.12; 95 % confidence interval [95 % CI], 1.01-1.24), older age (aHR per SD increase, 1.28; 95 % CI, 1.17-1.39), one or more comorbidities (aHR, 1.65; 95 % CI, 1.05-2.59), and impaired chair-stand test (aHR, 1.35; 95 % CI, 1.01-1.82). The second SMM quartile was associated with functional decline (aHR, 1.39; 95 % CI, 1.06-1.84) and the lowest quartile showed a nearly significant association (aHR, 1.29; 95 % CI, 0.98-1.72). Factors negatively associated with functional decline were living alone (aHR, 0.76; 95 % CI, 0.59-0.96), higher handgrip strength (aHR per SD increase, 0.88; 95 % CI, 0.78-0.88), and walking speed (aHR per SD increase, 0.86; 95 % CI, 0.77-0.96).

Conclusion

Low SMM was independently associated with functional decline within 4 years after adjustment for age, muscle strength, physical performance, and comorbidities in community-dwelling elderly women.