241 Particularities of the epidemiology of lower-extremities peripheral artery disease in Central Africa

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• 作者：Maë ; lenn Guerchet¹ ; Victor Aboyans² ; Pascal M&rsquo ; Belesso³ ; Alain Maxime Mouanga⁴ ; Johanna Salazar² ; Bebene Bandzouzi⁵ ; André ; Tabo⁶ ; Philippe Lacroix² ; Pierre-Marie Preux¹
• 刊名：Archives of Cardiovascular Diseases Supplements
• 出版年：2010
• 出版时间：January 2010
• 年：2010
• 卷：2
• 期：1
• 页码：77
• 全文大小：74 K

文摘

Background

In the western countries, a high prevalence of lower-extremities peripheral artery disease (LE-PAD) is reported in the elderly. The epidemiological transition in the developing countries might also involve this affection, but data regarding LE-PAD in Sub-Saharan Africa are unknown. We sought to determine the prevalence and risk factors for LE-PAD in the general elder population in 2 Sub-Saharan African countries: Congo and Central African Republic.

Methods

We performed 2 cross-sectional studies in the populations aged >65 years in two representative districts of Brazzaville, Congo and Bangui, Central African Republic. Demographic data, as well as medical history, were collected along with clinical and biological data to determine the traditional cardiovascular disease risk factors. The ankle-brachial index (ABI) was used to define LE-PAD, when ABI <0.90. An ABI >1.40 was considered to define medial calcinosis (MC).

Results

Among the 997 participants (age 73.6+6.5 yrs, 40.7 % males), 239 (24.0 % ) had LE-PAD, while 69 (6.9 % ) had MC. Adjusted for age, gender and study site, factors significantly associated with LE-PAD were hypertension (OR=1.75, 95 % CI: 1.24-2.48, p=0.002) and daily alcohol consumption (OR=0.72, 95 % CI: 0.53-0.98, p=0.04). A borderline association was found with a body-mass index >30kg/m² (OR=1.56, 95 % CI: 0.95-2.58, p=0.08). Of note, neither smoking nor diabetes were found as significant associated risk factors. Adjusted for age, gender and study site, factors significantly associated with MC were schooling (vs. no school education, OR=3.20, 95 % CI: 1.69-6.04, p=0.0003) and hypertension (OR=0.38, 95 % CI: 0.22-0.66, p=0.0006), while alcohol consumption (OR=0.63, 95 % CI: 0.37-1.07, p=0.09) and heart rate (OR=1.23, 95 % CI: 0.98-1.56, p=0.07) presented a borderline association.

Conclusions

In this first population study in Central Africa, we found a very high prevalence of LE-PAD in the elderly, and highlight particularities regarding the associated risk factors, different from data published in western countries.