Achieving Efficient Manufacturing and Quality Assurance through Synthetic Cell Therapy Design

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• 作者：Yonatan Y. Lipsitz¹ ; Patrick Bedford² ; ⁴ ; Anthony H. Davies³ ; Nicholas E. Timmins⁴ ; Peter W. Zandstra¹ ; ⁴ ; ⁵ ; ⁶ ; ^{peter.zandstra@utoronto.ca}
• 刊名：Cell Stem Cell
• 出版年：2017
• 出版时间：5 January 2017
• 年：2017
• 卷：20
• 期：1
• 页码：13-17
• 全文大小：649 K
• 卷排序：20

文摘

New methods to manipulate gene and cell state can be used to engineer cell functionality, simplify quality assessment, and enhance manufacturability. These strategies could help overcome unresolved cell therapy manufacturing challenges and complement frameworks to design quality into these complex cellular systems, ultimately increasing patient access to living therapeutics.