Exploring binding properties of sertraline with human serum albumin: Combination of spectroscopic and molecular modeling studies
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- 作者：Mohsen Shahlaeia ; b ; mshahlaei@kums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; mohsenshahlaei@yahoo.com" class="auth_mail" title="E-mail the corresponding author ; Behnoosh Rahimic ; Amin Nowroozid ; Mohammad Reza Ashrafi-Kooshke ; Komail Sadrjavadid ; Reza Khodarahmie ; f ; rkhodarahmi@kums.ac.ir" class="auth_mail" title="E-mail the corresponding author ; rkhodarahmi@mbrc.ac.ir" class="auth_mail" title="E-mail the corresponding author
- 关键词：Sertraline ; Human serum albumin ; Drug binding ; Ligand&ndash ; protein interaction
- 刊名：Chemico-Biological Interactions
- 出版年：2015
- 出版时间：5 December 2015
- 年：2015
- 卷：242
- 期：Complete
- 页码：235-246
- 全文大小：2199 K
文摘
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Hydrophobic as well as hydrophilic residues of HSA play an important role in the binding reaction.
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The drug has only one primary binding site on HSA.
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SER can interact with HSA without large affecting the secondary structure of the protein.