Trimeric HIV-1-Env Structures Define Glycan Shields from Clades A, B, and G
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- 作者：Guillaume B.E. Stewart-Jones1 ; Cinque Soto1 ; Thomas Lemmin1 ; 2 ; Gwo-Yu Chuang1 ; Aliaksandr Druz1 ; Rui Kong1 ; Paul V. Thomas1 ; Kshitij Wagh3 ; Tongqing Zhou1 ; Anna-Janina Behrens4 ; Tatsiana Bylund1 ; Chang W. Choi1 ; Jack R. Davison5 ; Ivelin S. Georgiev1 ; M. Gordon Joyce1 ; Young Do Kwon1 ; Marie Pancera1 ; Justin Taft1 ; Yongping Yang1 ; Baoshan Zhang1 ; Sachin S. Shivatare6 ; Vidya S. Shivatare6 ; Chang-Chun D. Lee6 ; Chung-Yi Wu6 ; Carole A. Bewley5 ; Dennis R. Burton7 ; 8 ; Wayne C. Koff9 ; Mark Connors10 ; Max Crispin4 ; Ulrich Baxa11 ; Bette T. Korber3 ; Chi-Huey Wong6 ; 12 ; John R. Mascola1 ; Peter D. Kwong1 ; pdkwong@nih.gov" class="auth_mail" title="E-mail the corresponding author
- 刊名：Cell
- 出版年：2016
- 出版时间：5 May 2016
- 年：2016
- 卷：165
- 期：4
- 页码：813-826
- 全文大小：6077 K
文摘
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Crystallographic (3.4–3.7 Å) visualization of the HIV-1 glycan shield
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Structures delineate a taxonomy of N-linked glycan-glycan interactions
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Crowded and dispersed glycans are differently ordered, processed, and conserved
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HIV-1-neutralizing antibodies recognizing the closed Env trimer accommodate glycan