Synthesis of polysubstituted pyridines via reactions of chalcones and malononitrile in alcohols using Amberlite IRA-400 (OH^?)

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• 作者：Kiumars Bahrami ; Mohammad M. Khodaei ; Fardin Naali ; Behrooz H. Yousefi
• 关键词：Polysubstituted pyridine ; Ion-exchange resin ; Multicomponent reaction ; Chalcones ; Malononitrile ; Solid base catalyst
• 刊名：Tetrahedron Letters
• 出版年：2013
• 出版时间：25 September, 2013
• 年：2013
• 卷：54
• 期：39
• 页码：5293-5298
• 全文大小：1926 K

文摘

Polysubstituted pyridine derivatives were synthesized through economical one-pot multicomponent reactions of different ¦Á,¦Â-unsaturated ketones, malononitrile, and ethanol or methanol in the presence of Amberlite IRA-400 (OH^?) at room temperature. The catalyst is recyclable several times without substantial loss of activity. Other valuable features include the wide range of functional group tolerance, easy and clean synthesis with a simple work-up procedure, and excellent yields under mild conditions.