Body composition, smoking, and spontaneous dizygotic twinning

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• 作者：Chantal Hoekstra ; Gonneke Willemsen ; C.E.M. Toos van Beijsterveldt ; Cornelius B. Lambalk ; Grant W. Montgomery ; Dorret I. Boomsma
• 关键词：Body composition ; smoking ; educational attainment ; maternal age ; gravidity ; multiple pregnancies
• 刊名：Fertility and Sterility
• 出版年：2010
• 出版时间：February 2010
• 年：2010
• 卷：93
• 期：3
• 页码：885-893
• 全文大小：128 K

文摘

class=""h4"">Objective

To examine differences in body composition and smoking between mothers of spontaneous monozygotic and dizygotic twins, while taking into account maternal age, gravidity, and educational attainment.

class=""h4"">Design

Retrospective cohort study.

class=""h4"">Setting

The Netherlands Twin Register.

class=""h4"">Patient(s)

Mothers of twins (n = 19,357) registered with the Netherlands Twin Register. Data were selected from mothers of spontaneous monozygotic twins (MZ; n = 5663) and mothers of spontaneous dizygotic twins (DZ; n = 8515).

class=""h4"">Intervention(s)

None.

class=""h4"">Main Outcome Measure(s)

The odds of having spontaneous DZ twins versus spontaneous MZ twins as a function of height, body mass index (BMI), and smoking before pregnancy, after accounting for age, gravidity, and educational attainment.

class=""h4"">Result(s)

Compared with spontaneous MZ twinning, spontaneous DZ twinning is significantly associated with increasing height (odds ratio, 1.6; 95 % confidence interval [CI], 1.5–1.8 for the tallest versus the shortest height quartile), an increased BMI (odds ratio, 1.3; 95 % CI, 1.1–1.4 for overweight vs. normal weight), and smoking before the twin pregnancy (odds ratio, 1.4; 95 % CI, 1.3–1.5 for smoker vs. nonsmoker). Maternal age and gravidity, but not educational attainment, had to be included in the model.

class=""h4"">Conclusion(s)

Spontaneous dizygotic twinning is associated with body composition and smoking.