Effect of short-term vitamin D supplementation on markers of vascular health in South Asian women living in the UK - A randomised controlled trial

详细信息    查看全文

• 作者：Miles D. Witham ; Fiona Adams ; Golam Kabir ; Gwen Kennedy ; Jill J.F. Belch ; Faisel Khan
• 关键词：Vitamin D ; Randomised controlled trial ; Endothelial function ; Arterial stiffness
• 刊名：Atherosclerosis
• 出版年：2013
• 出版时间：October, 2013
• 年：2013
• 卷：230
• 期：2
• 页码：293-299
• 全文大小：478 K

文摘

Objective

Low vitamin D levels and risk factors for vascular disease are both common in South Asian women. This trial evaluated whether vitamin D supplementation could improve markers of vascular health in South Asian women with low 25-hydroxyvitamin D levels.

Methods

Parallel-group, double-blind, randomised placebo-controlled trial. Healthy South Asian women with baseline serum 25-hydroxyvitamin D levels of <75?nmol/L were randomised to receive a single dose of 100,000 units oral vitamin D3 or matching placebo. Outcomes were measured at baseline, 4 and 8 weeks. The primary outcome was change in endothelial function measured using brachial artery flow-mediated dilatation. Secondary outcomes included blood pressure, arterial stiffness, microvascular function measured using laser Doppler iontophoresis, insulin resistance, serum lipids, circulating markers of inflammation, thrombosis and adipokines.

Results

50 women were randomised, 25 to each group. Mean age was 41 years; mean baseline 25-hydroxyvitamin D level was 27?nmol/L. 25-Hydroxyvitamin D levels rose in the vitamin D group relative to the placebo group by 4 weeks (16?nmol/L, 95 % CI 11 to 21, p?<?0.001). There was no improvement in flow-mediated dilatation in the vitamin D group relative to placebo at 4 weeks (0.1 % , 95 % CI??0.9 to 1.1, p?=?0.84) or 8 weeks (0.0 % , 95 % CI??1.4 to 1.4, p?=?0.98). There was no improvement in cholesterol, insulin resistance or markers of inflammation. Both platelet activation inhibitor-1 and tissue plasminogen activator levels fell significantly in the vitamin D group relative to placebo at 8 weeks.

Conclusion

A single large dose of vitamin D3 did not improve blood pressure or endothelial function in South Asian women with low baseline 25-hydroxyvitamin D levels.

Trial registration

.