La Piedad Michoacán Mexico Virus V protein antagonizes type I interferon response by binding STAT2 protein and preventing STATs nuclear translocation
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- 作者：Giuseppe Pisanellia ; b ; d ; Maudry Laurent-Rollea ; b ; Balaji Manicassamya ; b ; 1 ; Alan Belicha-Villanuevaa ; b ; Juliet Morrisona ; b ; 2 ; Bernardo Lozano-Dubernarde ; Felipa Castro-Peraltae ; Giuseppe Iovaned ; Adolfo Garcí ; a-Sastre.a ; b ; c ; adolfo.garcia-sastre@mssm.edu" class="auth_mail" title="E-mail the corresponding author
- 关键词：(LPMV) La Piedad Michoacan Mexico Virus ; LPMV-V ; STAT2 ; Interferon-signaling antagonist
- 刊名：Virus Research
- 出版年：2016
- 出版时间：2 February 2016
- 年：2016
- 卷：213
- 期：Complete
- 页码：11-22
- 全文大小：3756 K
文摘
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La Piedad Michoacán Mexico Virus (LPMV) V protein antagonizes type I but not type II IFN signaling.
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Type I IFN interferon-signaling inhibition is due to the binding with LPMV-V protein with STAT2 protein, a fundamental component of type I IFN cascade.
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LPMV-V protein does prevent the IFN-induced phosphorylation and nuclear translocation of STAT1 and STAT2 thereby inhibiting cellular responses to IFN α/β.
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The last 18 amino acids are necessary for binding to STAT2 in human and swine origin cells.