Unanchored K48-Linked Polyubiquitin Synthesized by the E3-Ubiquitin Ligase TRIM6 Stimulates the Interferon-IKK蔚 Kinase-Mediated Antiviral Response
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- 作者：Ricardo Rajsbaum1 ; 2 ; 7 ; Gijs A. Versteeg1 ; 2 ; 4 ; 7 ; Sonja Schmid1 ; Ana M. Maestre1 ; Alan Belicha-Villanueva1 ; 2 ; Carles Martí ; nez-Romero1 ; 2 ; Jenish R. Patel1 ; 2 ; Juliet Morrison1 ; 2 ; Giuseppe Pisanelli1 ; 2 ; 5 ; Lisa Miorin1 ; 2 ; Maudry Laurent-Rolle1 ; 2 ; Hong M. Moulton6 ; David A. Stein6 ; Ana Fernandez-Sesma1 ; Benjamin R. tenOever1 ; 2 ; Adolfo Garcí ; a-Sastre1 ; 2 ; 3 ; adolfo.garcia-sastre@mssm.edu" class="auth_mail
- 刊名：Immunity
- 出版年：19 June 2014
- 年：2014
- 卷：40
- 期：6
- 页码：880-895
- 全文大小：4886 K
文摘
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TRIM6 plays a critical role in innate immune activation
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TRIM6 and the E2 conjugase UbE2K synthesize unanchored K48-linked ubiquitin chains
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Unanchored K48-linked ubiquitin chains activate the IKK蔚 kinase
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TRIM6 couples IFN伪R engagement to activation of the IKK蔚 kinase for ISG induction