Early-onset severe axonal neuropathy associated with optic atrophy and vocal cord paresis due to a mitofusin 2 mutation

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• 作者：Eppie M. Yiu ; Lloyd K. Shield ; Leslie J. Roberts ; Desiré ; e du Sart ; Belinda Chong ; Justin O’ ; Day ; Monique M. Ryan
• 关键词：Stroke ; rTMS ; Transcranial magnetic stimulation ; Motor cortex ; Plasticity
• 刊名：Clinical Neurophysiology
• 出版年：2008
• 出版时间：March 2008
• 年：2008
• 卷：119
• 期：3
• 页码：e20
• 全文大小：34 K

文摘

Changes in cerebral cortex excitability have been demonstrated after a stroke and are considered relevant for recovery. Repetitive transcranial magnetic stimulation (rTMS) of the brain can modulate cerebral cortex excitability and, when rTMS is given as theta burst stimulation (TBS), LTP- or LTD-like changes can be induced. The aim of present study was to evaluate the effects of TBS on cortical excitability in acute stroke.

Methods

In 12 acute stroke patients, we explored the effects of facilitatory TBS of the affected hemisphere and of inhibitory TBS of the unaffected hemisphere on cortical excitability to single-pulse transcranial magnetic stimulation (TMS) on both sides. The effects produced by TBS in patients were compared with those observed in a control group of age-matched healthy individuals.

Results

In patients, both the facilitatory TBS of the affected motor cortex and the inhibitory TBS of the unaffected motor cortex produced a significant increase of the amplitude of MEPs evoked by stimulation of the affected hemisphere. The effects observed in patients were comparable to those observed in controls.

Conclusions

Facilitatory TBS over the stroke hemisphere and inhibitory TBS over the intact hemisphere in acute phase enhance the excitability of the lesioned motor cortex.

Significance

TBS might be useful to promote cortical plasticity in stroke patients.