- 作者：Yan-Feng Chen ; MD<sup>?sup> ; Wei-Dong Zhang ; MD<sup>&dagger ; sup> ; Chuan-Zheng Sun ; MD<sup>&Dagger ; sup> ; Dian OuYang ; MD<sup>?sup> ; Wen-Kuan Chen ; MD<sup>?sup> ; Rong-Zhen Luo ; MD<sup>¶ ; sup> ; Ming-Wei Wu ; MD<sup>#sup><sup> ; sup><sup>belll@126.comsup>
- 刊名：Journal of Oral and Maxillofacial Surgery
- 出版年：2012
- 出版时间：October, 2012
- 年：2012
- 卷：70
- 期：10
- 页码：2466-2479
- 全文大小：8443 K
ss=""h4"">Purpose
To increase the understanding of head and neck Castleman disease (CD) and to improve its diagnosis and management.ss=""h4"">Patients and Methods
A retrospective study was performed on the medical records of 14 patients with cervical CD treated at the Sun Yat-sen University Cancer Center from January 2000 through December 2009. The predictor variables were age, gender, site, size, and treatment modality. The outcome variables were survival time and recurrence.
ss=""h4"">Results
Neck level II (9/14) was the most common site for CD. On computed tomogram, all 14 cases appeared as nodular and cylindrical-shaped lesions growing along the neck. Computed tomogram showed a uniform density and clear margins of the lesions. Thirteen cases with hyaline-vascular type CD showed significant enhancement on enhancing computed tomographic scans. One case with plasma-cell type CD accompanied by Hodgkin lymphoma showed mild heterogeneous enhancement and a strong vascular shadow inside the lesion. Thirteen patients with unicentric CD underwent regional resection. Follow-up time ranged from 14 to 132 months, during which none of the patients relapsed.
ss=""h4"">Conclusions
The results of this study suggest that head and neck CD has a low incidence and that the most common site is unilateral level II. Regional resection was the first choice for the treatment of unicentric CD. Overall, chemotherapy was associated with a poor prognosis in patients with multicentric CD. Future studies will focus on the early diagnosis and treatment of multicentric CD. Long-term follow-up is also necessary.